Coseicure Sheep Bolus

https://www.bimeda.ie/media/k2/attachments/1COS011_Data_Sheet.pdf

 

COSEICURE DATA

SHEET

Trace element bolus containing copper, cobalt, iodine and selenium

EACH BOLUS CONTAINS:

13.4% w/w copper

0.15% w/w selenium

0.5% w/w cobalt

1.0% w/w iodine

 

USES

For the supply of copper, cobalt, selenium and iodine in

sheep over 30kg. The bolus supplies these trace elements

at a controlled and constant rate for up to 8 months.

EACH BOLUS CONTAINS:

13.4% w/w copper

0.15% w/w selenium

0.5% w/w cobalt

1.0% w/w iodine

 

PRESENTATION

Continuous release intraruminal device.

 

HOW TO ADMINISTER & QUANTITIES TO PROVIDE

Remove the bolus from the foil and ensure the bolus is as

close to body temperature as possible at the time of

administration.

Sheep over 30kg: 1 bolus

For all classes of sheep over 30 kg live weight.

One CoseIcure bolus may be given at any convenient time

in the sheep management year. It is particularly

appropriate to give CoseIcure 2 to 3 weeks prior to tupping

for cover at this critical time, through to lambing and peak

lactation.

Administer orally using an applicator which delivers the

bolus directly into the top of the gullet. Great care should

be taken not to cause any injury by rough handling or by

placing the applicator too far inside the throat of the

animal. Ensure that each animal has swallowed the bolus

by holding the mouth closed and observing the animal for

a short time. Gentle massage of the throat may facilitate

swallowing of the boluses. To minimise the risk of

regurgitation, avoid rough handling of animals.

In the event of suspected overdose see carton.

 

CONTRA-INDICATIONS & WARNINGS

Do not administer to non-ruminating lambs or to animals

weighing less than 30kg body weight.

 

SPECIAL WARNING FOR EACH TARGET SPECIES

The product is not intended for treatment of acute clinical

conditions such as nutritional muscular dystrophy.

 

SPECIAL PRECAUTIONS FOR USE

(i)Special precautions for use in animals

Do not feed copper supplemented rations nor feed stuffs

high in naturally occurring copper to sheep receiving

CoseIcure nor administer copper or selenium by injection

or copper orally while the boluses are still active (8

months), unless advised by a veterinary surgeon. In cases

where the trace element status of a flock is uncertain it is

advisable to seek veterinary advice.

Do not administer to breeds known to be susceptible to

copper toxicity.

Do not administer to sheep that are going to be housed for

longer than 6 weeks prior to lambing.

Do not administer any aids to alter dissolution of the bolus.

The boluses are sensitive to sudden temperature

changes such as those that may occur when very cold

boluses are swallowed by an animal. Therefore it is

important that the bolus is as close to body temperature

as possible, at administration to prevent the

development of fine cracks that may change the activity

of the bolus.

 

ii. Special precautions to be taken by the person

administering the bolus to animals.

In order to minimise the risk of contact allergy, wear gloves

when handling this product.

 

OVERDOSE (SYMPTOMS, EMERGENCY PROCEDURES,

ANTIDOTES), IF NECESSARY

Do not feed copper supplemented rations nor feed stuffs

high in naturally occurring copper to sheep receiving

CoseIcure nor administer copper or selenium by injection

or copper orally while the boluses are still active (8

months), unless advised by a veterinary surgeon.

Clinical signs of copper toxicity, which normally will only

occur in cases of severe copper overdosage include

jaundice, malaise, an acute drop in milk yield and, later,

haemoglobinuria. Signs of selenium toxicity include CNS

changes, muscle weakness, vomiting, anorexia, depression,

incoordination and, after prolonged exposure, respiratory

problems. In these circumstances, intravenous

administration of copper and/or selenium chelating has

been used.

 

WITHDRAWAL PERIODS

Sheep: Meat zero days; milk zero hours

 

PHARMACEUTICAL INFORMATION AND PRECAUTIONS

Pharmacotherapeutic group: selenium combinations

 

PHARMACODYNAMIC PROPERTIES

The active substances are the essential trace elements

copper, cobalt, selenium and iodine. The boluses are

designed to dissolve slowly throughout the grazing season

(up to 8 months), releasing copper, cobalt, selenium and

iodine.

Copper is an integral part of several enzymes with oxidase

function e.g. caeruloplasmin, monoamine oxidase,

cytochrome oxidase, tyrosinase, lysyl oxidase, cytochrome

C and superoxide dismutase. Thus copper is essential for a

variety of body functions including growth. In addition,

extra copper supplementation is essential in cases of

infertility due to the formation of thiomolybdates with

molybdenum.

Cobalt is an integral part in Vitamin B12 (cyanocobalamin),

which is important for several metabolic functions. This

vitamin is synthesised by micro-organisms in the rumen

and is absorbed from there into the systemic circulation.

Vitamin B 12 acts as a co-enzyme in several metabolic

pathways and in ruminants its main role is in the

metabolism of propionate, which is required for synthesis

of glucose via succinate in the liver.

Selenium is an integral part in the glutathione peroxidase

(GSHPx) enzymes, which are involved in the protection

from oxidant stress. These enzymes have a synergistic role

with vitamin E and other antioxidants in removing toxic

peroxides from tissue and preventing oxidative damage to

membranes. Selenium is required in the thyroid gland for

the conversion of T4 to T3, the active thyroxine molecule

as selenium is required in the iodothyronine deiodinase

enzymes.

Iodine is required for the synthesis of triiodothyronine (T3)

and tetraiodothyronine (thyroxine T4) in the thyroid gland.

These hormones are derivatives of the amino acid tyrosine.

The function of the iodine hormones is to affect basal

metabolic rate and thus accelerate growth and increase

the oxygen consumption. A deficiency of iodine will result

in impaired production of these hormones and as a result

goitre (enlarged thyroid gland) will be seen. The clinical

consequences of iodine deficiency are seen predominantly

as reproductive abnormalities, with ewes giving birth to

weak or dead young. Note that this condition can also arise

due to selenium deficiency, which can reduce the

conversion of T4 into the active T3 form, and also due to

the consumption of foods containing goitrogens.

Goitrogens are substances particularly found in brassicas

(kale, cabbage, rape) which inhibit the iodination of

tyrosine and hence the synthesis of thyroxine.

PHARMACOKINETIC PARTICULARS

Following oral administration the boluses lodge in the

reticulum where they dissolve slowly over a period of up to

8 months. The ultimate breakdown products are copper,

cobalt, iodine and selenium in ionic form. The boluses

provide a source of these trace elements at levels

compatible with the animal’s daily requirements

 

PHARMACEUTICAL PARTICULARS

List of excipients

Phosphorus (V)-oxide

Sodium oxide

Magnesium oxide

Other oxides

 

SPECIAL PRECAUTIONS FOR STORAGE

Store in a dry place. Do not freeze. Protect from frost. Once

the package has been opened, store unused boluses in the

plastic tray in the original packaging in an airtight

container.

 

NATURE AND COMPOSITION OF IMMEDIATE PACKAGING

Each foil pack contains 10 boluses; equivalent to 10 doses.

5 foils are provided per unit i.e 50 boluses per unit.

 

SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED

PRODUCT OR WASTE MATERIALS DERIVED FROM THE

USE OF SUCH PRODUCTS

Any unused product or waste materials should be disposed

of in accordance with local requirements.

LEGAL CATEGORY

Complementary dietetic feedstuff.

 

For further information and queries, please contact

Bimeda:

UK Office: +44 (0) 1248725400

Ireland Office: +353 (0) 1 466 7900

Please consult your local trained animal health advisor

before using. Please Use Responsibly

Applicator Instructions 

http://www.bimeda.ie/media/k2/attachments/Bimeda_Sheep_Bolus_Administration_Guidelines_2.pdf